Plant-Derived Chlorophyll Derivatives Loaded Liposome for Tri-Model Imaging Guided Photodynamic Therapy
Plant-derived chlorophyll derivatives with porphyrin ring structure and intrinsic photosynthesis have been widely used in biomedicine for cancer theranostics. Owing to the poor water-solubility, chlorophyll derivatives are very difficult for biomedical applications. In this work, a liposome-encapsulated chlorophyll derivative Pyropheophorbide acid (PPa) (liposome/PPa) nanoparticles are designed for tri-model imaging guided photodynamic therapy (PDT) of cancer. The obtained liposome/PPa nanoparticles significantly enhance the water-solubility of PPa, prolong the blood circulation and optimize the bio-distribution in mice after intravenous injection. Utilizing the intrinsic fluorescence, high near-infrared (NIR) absorbance and extra radiolabeling, liposome/PPa nanoparticles could be used as excellent contrast agent for multimodal imaging including fluorescence (FL) imaging, photoacoustic (PA) imaging and SPECT/CT imaging. Under 690 nm laser irradiation at low power density, liposome/PPa nanoparticles significantly inhibit the tumor growth, further demonstrating the therapeutic efficiency of PDT of PPa. Therefore, our work developed liposome/PPa nanoparticles as multifunctional nanoagents for multimodal imaging guided PDT of cancer. It will further prompt the clinical applications of PPa in the future.
- This article is part of the themed collection: 2019 Nanoscale HOT Article Collection