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Plant-Derived Chlorophyll Derivatives Loaded Liposome for Tri-Model Imaging Guided Photodynamic Therapy

Abstract

Plant-derived chlorophyll derivatives with porphyrin ring structure and intrinsic photosynthesis have been widely used in biomedicine for cancer theranostics. Owing to the poor water-solubility, chlorophyll derivatives are very difficult for biomedical applications. In this work, a liposome-encapsulated chlorophyll derivative Pyropheophorbide acid (PPa) (liposome/PPa) nanoparticles are designed for tri-model imaging guided photodynamic therapy (PDT) of cancer. The obtained liposome/PPa nanoparticles significantly enhance the water-solubility of PPa, prolong the blood circulation and optimize the bio-distribution in mice after intravenous injection. Utilizing the intrinsic fluorescence, high near-infrared (NIR) absorbance and extra radiolabeling, liposome/PPa nanoparticles could be used as excellent contrast agent for multimodal imaging including fluorescence (FL) imaging, photoacoustic (PA) imaging and SPECT/CT imaging. Under 690 nm laser irradiation at low power density, liposome/PPa nanoparticles significantly inhibit the tumor growth, further demonstrating the therapeutic efficiency of PDT of PPa. Therefore, our work developed liposome/PPa nanoparticles as multifunctional nanoagents for multimodal imaging guided PDT of cancer. It will further prompt the clinical applications of PPa in the future.

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Supplementary files

Publication details

The article was received on 12 Aug 2019, accepted on 08 Oct 2019 and first published on 10 Oct 2019


Article type: Paper
DOI: 10.1039/C9NR06941K
Nanoscale, 2019, Accepted Manuscript

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    Plant-Derived Chlorophyll Derivatives Loaded Liposome for Tri-Model Imaging Guided Photodynamic Therapy

    H. Zhou, L. Xia, J. Zhong, S. Xiong, X. Yi, L. Chen, R. Zhu, Q. Shi and K. Yang, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR06941K

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