Jump to main content
Jump to site search


Boron clusters as a platform for new materials: composites of nucleic acids and oligofunctionalized carboranes (C2B10H12) and their assembly into functional nanoparticles

Author affiliations

Abstract

Nucleic acids are key biomolecules in all life forms. These biomolecules can encode and transfer information via Watson-Crick base-pairing interactions and can form double-stranded structures between complementary sequences with high precision. These properties make nucleic acids extremely successful in applications in materials science as nanoconstruction materials. Herein, we describe a method for the automated synthesis of “oligopeds”, which are building blocks based on the boron cluster structure equipped with short DNA adapters; these building blocks assemble into functional nanoparticles. The obtained, well defined, torus-like structures are the first DNA nanoconstructs based on a boron cluster scaffold. The results indicate the potential of boron clusters in DNA nanoconstruction and open the way for the design of entirely new types of buildings blocks based on polyhedral heteroborane geometry and its unique properties. The use of antisense oligonucleotides as DNA adapters illustrates one of the possible applications of the obtained nanoconstructs as vectors for therapeutic nucleic acids.

Graphical abstract: Boron clusters as a platform for new materials: composites of nucleic acids and oligofunctionalized carboranes (C2B10H12) and their assembly into functional nanoparticles

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Jul 2019, accepted on 30 Oct 2019 and first published on 30 Oct 2019


Article type: Paper
DOI: 10.1039/C9NR06550D
Nanoscale, 2019, Advance Article

  •   Request permissions

    Boron clusters as a platform for new materials: composites of nucleic acids and oligofunctionalized carboranes (C2B10H12) and their assembly into functional nanoparticles

    D. Kaniowski, K. Ebenryter-Olbinska, K. Kulik, S. Janczak, A. Maciaszek, K. Bednarska-Szczepaniak, B. Nawrot and Z. Lesnikowski, Nanoscale, 2019, Advance Article , DOI: 10.1039/C9NR06550D

Search articles by author

Spotlight

Advertisements