Jump to main content
Jump to site search


Increasing dielectric loss of a graphene oxide nanoparticle to enhance the microwave thermoacoustic imaging contrast of breast tumor

Author affiliations

Abstract

Microwave-induced thermoacoustic imaging (MTAI) utilizes the high dielectric contrast of tissues in the microwave range, and, combined with the high resolution of ultrasound imaging, can noninvasively obtain anatomical and functional structure information. However, adequate contrast in certain indications (e.g., breast tumor in their early stages) can be difficult to achieve due to the minimal dielectric difference in the target tissues. A tumor specific targeting nanoparticle with high dielectric loss would enhance MTAI contrast in such applications. In this work, we propose a physics-principle-based technique that increases the dielectric loss of a nanoparticle by increasing its atomic defect to generate an amplified thermoacoustic signal. In principle, bovine serum albumin loaded on graphene oxide (GO) serves as a reductant to create additional vacancies in GO to produce more electric dipoles. Upon pulsed microwave irradiation, the defect dipoles are polarized repeatedly, causing transient heating and thermoelastic expansion, and ultimately generating an amplified acoustic wave. This hypothesis was tested in vitro and in vivo with a breast tumor animal model. The results demonstrate that the nanoparticle can effectively enhance the MTAI contrast of breast tumors. The physics-principle-based technique is likely to contribute to early breast tumor imaging.

Graphical abstract: Increasing dielectric loss of a graphene oxide nanoparticle to enhance the microwave thermoacoustic imaging contrast of breast tumor

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Jul 2019, accepted on 30 Oct 2019 and first published on 30 Oct 2019


Article type: Communication
DOI: 10.1039/C9NR06549K
Nanoscale, 2019, Advance Article

  •   Request permissions

    Increasing dielectric loss of a graphene oxide nanoparticle to enhance the microwave thermoacoustic imaging contrast of breast tumor

    C. Yuan, B. Qin, H. Qin and D. Xing, Nanoscale, 2019, Advance Article , DOI: 10.1039/C9NR06549K

Search articles by author

Spotlight

Advertisements