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Controllable Growth of Au Nanostructures onto MoS2 Nanosheets for Dual-modal Imaging and Photothermal-radiation Combined Therapy

Abstract

Multifunctional theranostic nanoagents are attractive to realize comprehensive imaging and effective treatment of tumours. Herein, a novel strategy is developed to controllably guide the epitaxial growth of gold nanostructures onto MoS2 nanosheets. The as-prepared MoS2-Au nanostructures (MA) manifest an enhanced near-infrared (NIR) absorbance with strong photostability. After modification, the obtained MA-PEG shows strong X-ray attenuation and photothermal conversion ability, promising for CT and photoacoustic imaging with an enhanced intensity in tumours. Moreover, in vivo photothermal and radiation therapy with MA-PEG achieves synergistic tumour treatment efficiency through hyperthermia elevated oxygenation level and sensitized radiation therapy. This work develops a unique MA nanostructure with enhanced NIR absorbance and strong photoelectric absorbance as a multifunctional theranostic agent with great potential for dual-modal imaging guided photothermal-radiation therapy of cancer.

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Publication details

The article was received on 30 Jul 2019, accepted on 24 Oct 2019 and first published on 25 Oct 2019


Article type: Paper
DOI: 10.1039/C9NR06513J
Nanoscale, 2019, Accepted Manuscript

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    Controllable Growth of Au Nanostructures onto MoS2 Nanosheets for Dual-modal Imaging and Photothermal-radiation Combined Therapy

    T. Liu, S. Shen, Y. Huang, X. Zhang, Z. Lai, T. H. Tran, Z. Liu and L. Cheng, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR06513J

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