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Construction of CPs@MnO2–AgNPs as a multifunctional nanosensor for glutathione sensing and cancer theranostics

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Abstract

A multifunctional nanosensor of CPs@MnO2–AgNPs was constructed for sensitive and selective sensing of GSH and cancer theranostics in this work. The CPs@MnO2 nanocomposite was synthesized by capping MnO2 onto carbon nanoparticles through an in situ redox reaction under ultrasonication. AgNPs with fluorescence were obtained through a silver-mirror-like reaction using BSA as both a template and reductant and further anchored onto the surface of CPs@MnO2 through electrostatic interaction to construct the CPs@MnO2–AgNP nanocomposite. The fluorescence of AgNPs was effectively quenched by MnO2 through an inner filter effect and a static quenching effect and further recovered by GSH owing to the unique redox reaction between GSH and MnO2. Therefore, a novel fluorescent turn-on nanosensor was established for GSH sensing in vitro and in vivo. For GSH sensing, a satisfactory linear range of 0.8–80 μM with a detection limit of 0.55 μM was obtained under optimal conditions. Moreover, by integrating the GSH-responsive fluorescence imaging capacity, the photothermal activity of carbon nanoparticles and the anticancer effect of AgNPs, the CPs@MnO2–AgNP nanocomposite was successfully applied for cancer theranostics. The fluorescence recognition of cancer was achieved by overexpressing GSH in cancer, meanwhile the photothermal therapy from CPs and chemotherapy from AgNPs jointly produced an enhanced therapeutic effect. This redox-responsive nanocomposite of CPs@MnO2–AgNPs improves the MnO2 nanomaterial-based applications in GSH sensing and cancer theranostics.

Graphical abstract: Construction of CPs@MnO2–AgNPs as a multifunctional nanosensor for glutathione sensing and cancer theranostics

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Publication details

The article was received on 28 Jul 2019, accepted on 13 Sep 2019 and first published on 16 Sep 2019


Article type: Paper
DOI: 10.1039/C9NR06443E
Nanoscale, 2019, Advance Article

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    Construction of CPs@MnO2–AgNPs as a multifunctional nanosensor for glutathione sensing and cancer theranostics

    Q. Wang, C. Wang, X. Wang, Y. Zhang, Y. Wu, C. Dong and S. Shuang, Nanoscale, 2019, Advance Article , DOI: 10.1039/C9NR06443E

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