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Biodegradable MnO2 nanosheet mediated hybridization chain reaction for imaging of human apurinic/apyrimidinic endonuclease 1 activity in living cells

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Abstract

A highly sensitive enzyme-free amplification assay for the detection of apurinic/apyrimidinic endonuclease 1 activity was developed. By incorporating biodegradable MnO2 nanosheets, in situ light up intracellular APE 1 activity was achieved.

Graphical abstract: Biodegradable MnO2 nanosheet mediated hybridization chain reaction for imaging of human apurinic/apyrimidinic endonuclease 1 activity in living cells

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Publication details

The article was received on 28 Jul 2019, accepted on 07 Oct 2019 and first published on 08 Oct 2019


Article type: Communication
DOI: 10.1039/C9NR06436B
Nanoscale, 2019, Advance Article

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    Biodegradable MnO2 nanosheet mediated hybridization chain reaction for imaging of human apurinic/apyrimidinic endonuclease 1 activity in living cells

    G. Li, J. Li and Q. Li, Nanoscale, 2019, Advance Article , DOI: 10.1039/C9NR06436B

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