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NanoMuscle: Controllable Contraction and Extension of Mechanically Interlocked DNA Origami

Abstract

Artificial molecular machines synthesized in supramolecular chemistry have attracted great interests in past decades. DNA origami presents an alternative way to construct nano-machines by directly designing its thermodynamically-stable state by DNA sequences. Here we construct a molecular device, named NanoMuscle, with mechanically interlocked DNA origami. NanoMuscle’s configuration – either extend or contract – can be controlled by adding specific DNA strands. We monitored NanoMuscle’s multistep synthesis with gel electrophoresis, and verified that monomers of NanoMuscle are interlocked at correct orientation with transmission electron microscopy (TEM). We then validated that NanoMuscle can switch between extended and contracted configuration. By converting binding energy from DNA hybridization and Brownian motion to mechanical movements, NanoMuscle may serve as a novel building block for future mesoscale machinery.

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Publication details

The article was received on 24 Jul 2019, accepted on 18 Nov 2019 and first published on 25 Nov 2019


Article type: Paper
DOI: 10.1039/C9NR06314E
Nanoscale, 2019, Accepted Manuscript

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    NanoMuscle: Controllable Contraction and Extension of Mechanically Interlocked DNA Origami

    Y. Chao, Y. Hong, C. Lee, S. Zhuang, M. Wu, Y. Lee, H. Lee, Y. He, H. Yu, Y. Huang, E. Chern and H. Jiang, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR06314E

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