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Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation

Abstract

Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D context, nanogrooved microdiscs, “topodiscs”, are produced as cell-carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.

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Supplementary files

Publication details

The article was accepted on 14 Aug 2019 and first published on 15 Aug 2019


Article type: Communication
DOI: 10.1039/C9NR06267J
Nanoscale, 2019, Accepted Manuscript

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    Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation

    I. M. Bjørge, I. S. Choi, C. R. Correia and J. Mano, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR06267J

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