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Issue 35, 2019
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Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation

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Abstract

Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, “topodiscs”, are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.

Graphical abstract: Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation

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Article information


Submitted
23 Jul 2019
Accepted
14 Aug 2019
First published
15 Aug 2019

Nanoscale, 2019,11, 16214-16221
Article type
Communication

Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation

I. M. Bjørge, I. S. Choi, C. R. Correia and J. F. Mano, Nanoscale, 2019, 11, 16214
DOI: 10.1039/C9NR06267J

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