Jump to main content
Jump to site search


γ-Cyclodextrin-based Metal-Organic Framework Embedded with Graphene Quantum Dots and Modified with PEGMA via SI-ATRP for Anticancer Drug Delivery and Therapy

Abstract

The γ-cyclodextrin-based metal-organic framework (γ-CD-MOF) composite was designed and prepared toward targeted anticancer drug delivery and cancer therapy. Large amounts of graphene quantum dots (GQDs) were embedded in the γ-CD-MOF matrix (denoted as GQDs@γ-CD-MOF) to endow γ-CD-MOF with strong fluorescence, which was then modified by pH responsive poly(ethyleneglycol)dimethacrylate (PEGMA) through surface initiated atom transfer radical polymerization (SI-ATRP) to fabricate the PEGMA@GQDs@γ-CD-MOF composite. Then, the cancer cell-targeted probe was ob-tained by immobilizing AS1411 aptamer over it (denoted as AS1411@PEGMA@GQDs@γ-CD-MOF) and exhibit pH-responsive release function and excellent targeting ability. Large amounts of antitumor drug, doxorubicin hydrochlo-ride (DOX), could be encapsulated within this composite due to the chemical-rich func-tionality, and the resultant pH-responsive DOX delivery system (denoted as DOX/AS1411@PEGMA@GQDs@γ-CD-MOF) displayed a higher DOX loading of 89.1% with sustained release than the pristine γ-CD-MOF and GQDs@γ-CD-MOF. The targeting specificity investigation revealed that this DOX delivery system was effectively internalized via the receptor mediated endocytosis with high selectivity. The in vivo anti-tumor study with tumor-bearing mice illustrated that the tumor growth can be effectively suppressed and partially ablated with negligible side effects after treatments. Therefore, the proposed AS1411@PEGMA@GQDs@γ-CD-MOF composite is promising for effec-tive DOX delivery and tumor growth inhibitation both in vitro and in vivo, showing a great potential for anticancer therapy.

Back to tab navigation

Supplementary files

Publication details

The article was received on 21 Jul 2019, accepted on 08 Oct 2019 and first published on 09 Oct 2019


Article type: Paper
DOI: 10.1039/C9NR06195A
Nanoscale, 2019, Accepted Manuscript

  •   Request permissions

    γ-Cyclodextrin-based Metal-Organic Framework Embedded with Graphene Quantum Dots and Modified with PEGMA via SI-ATRP for Anticancer Drug Delivery and Therapy

    Q. Jia, Z. Li, C. Guo, X. Huang, Y. Song, N. Zhou, M. Wang, Z. Zhang, L. He and M. Du, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR06195A

Search articles by author

Spotlight

Advertisements