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Issue 41, 2019
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Plasmonic bimetallic nanodisk arrays for DNA conformation sensing

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Abstract

The integration of large-scale 2D bimetallic Ag/Au nanodisk arrays with gold nanoparticles is developed for sensing DNA conformation with the assistance of 3D finite-difference time-domain simulation. The optimized system comprising Ag/Au nanodisk arrays and gold nanoparticles offers a more than 6-fold enhancement in surface plasmon resonance shift, enabling the feasibility for sensitive DNA detection with a detection limit down to 100 femtomolar. Importantly, owing to the distance-dependent nature of the surface plasmon signal, sensitive differentiation of DNA conformations can be achieved with a conventional optical measurement. This platform could provide new exciting capabilities for a reliable, reproducible, and label-free assay analysis for investigating the conformations of DNA and other biological molecules.

Graphical abstract: Plasmonic bimetallic nanodisk arrays for DNA conformation sensing

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Publication details

The article was received on 18 Jul 2019, accepted on 08 Sep 2019 and first published on 09 Sep 2019


Article type: Communication
DOI: 10.1039/C9NR06101K
Nanoscale, 2019,11, 19291-19296

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    Plasmonic bimetallic nanodisk arrays for DNA conformation sensing

    T. T. V. Nguyen, X. Xie, J. Xu, Y. Wu, M. Hong and X. Liu, Nanoscale, 2019, 11, 19291
    DOI: 10.1039/C9NR06101K

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