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Issue 44, 2019
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Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers

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Abstract

Synthetic glycopolymers are increasingly investigated as multivalent ligands for a range of biological and biomedical applications. This study indicates that glycopolymers with a fine-tuned balance between hydrophilic sugar pendant units and relatively hydrophobic polymer backbones can act as single-chain targeted nanocarriers for low molecular weight hydrophobic molecules. Non-covalent complexes formed from poly(triazolyl methacrylate) glycopolymers and low molecular weight hydrophobic guest molecules were characterised through a range of analytical techniques – DLS, SLS, TDA, fluorescence spectroscopy, surface tension analysis – and molecular dynamics (MD) modelling simulations provided further information on the macromolecular characteristics of these single chain complexes. Finally, we show that these nanocarriers can be utilised to deliver a hydrophobic guest molecule, Nile red, to both soluble and surface-immobilised concanavalin A (Con A) and peanut agglutinin (PNA) model lectins with high specificity, showing the potential of non-covalent complexation with specific glycopolymers in targeted guest-molecule delivery.

Graphical abstract: Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers

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Publication details

The article was received on 09 Jul 2019, accepted on 28 Aug 2019 and first published on 29 Oct 2019


Article type: Paper
DOI: 10.1039/C9NR05836B
Nanoscale, 2019,11, 21155-21166
  • Open access: Creative Commons BY license
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    Poly(triazolyl methacrylate) glycopolymers as potential targeted unimolecular nanocarriers

    J. Madeira do O, R. Foralosso, G. Yilmaz, F. Mastrotto, P. J. S. King, R. M. Xerri, Y. He, C. F. van der Walle, F. Fernandez-Trillo, C. A. Laughton, I. Styliari, S. Stolnik and G. Mantovani, Nanoscale, 2019, 11, 21155
    DOI: 10.1039/C9NR05836B

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