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Hypoxia-induced biosynthesis of gold nanoparticles in the living brain

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Abstract

While a large number of studies deal with biomedical applications of various types of nanoparticles synthesized using wet chemistry, we propose the concept of targeted biosynthesis of nanoparticles in the living brain. Here we demonstrate that the pathological biochemical process of accumulation of reduced pyridine nucleotides under deleterious conditions of brain hypoxia can be redirected to drive the biosynthesis of biocompatible Au nanoparticles from a precursor salt in situ in the immediate vicinity of the hypoxia site, thereby restoring the redox status of the brain.

Graphical abstract: Hypoxia-induced biosynthesis of gold nanoparticles in the living brain

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Publication details

The article was received on 09 Jul 2019, accepted on 01 Sep 2019 and first published on 20 Sep 2019


Article type: Communication
DOI: 10.1039/C9NR05794C
Nanoscale, 2019, Advance Article

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    Hypoxia-induced biosynthesis of gold nanoparticles in the living brain

    E. A. Rozhkova, B. Lee, J. A. Prasad, Y. Liu and E. V. Shevchenko, Nanoscale, 2019, Advance Article , DOI: 10.1039/C9NR05794C

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