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SERS-based particle tracking and molecular imaging in live cells: toward the monitoring of intracellular dynamics

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Abstract

Although diverse endogenous biomolecules involved in life processes are of major interest in cell biology, there is still a lack of suitable methods for studying biomolecules within live cells without labelling. Herein, we describe a near-infrared (NIR) surface-enhanced Raman scattering (SERS)-based particle tracking technique gathering chemical information inside live cells for monitoring their intracellular dynamics. The wide-field SERS imaging spectroscopy system facilitates high temporal resolution (200 ms) under high spatial resolution (512 × 512 pixels) for one live cell. With high spatiotemporal resolution and signal-to-background ratio, we show that the Raman signal from intracellular cargoes in live cells is sporadically observed and localized to a vesicular level.

Graphical abstract: SERS-based particle tracking and molecular imaging in live cells: toward the monitoring of intracellular dynamics

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Publication details

The article was received on 18 Jun 2019, accepted on 10 Aug 2019 and first published on 07 Sep 2019


Article type: Communication
DOI: 10.1039/C9NR05159G
Nanoscale, 2019, Advance Article

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    SERS-based particle tracking and molecular imaging in live cells: toward the monitoring of intracellular dynamics

    J. Kim, S. H. Nam, D. Lim and Y. D. Suh, Nanoscale, 2019, Advance Article , DOI: 10.1039/C9NR05159G

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