Jump to main content
Jump to site search


Recent advances in multiphoton microscopy combined with nanomaterials in the field of disease evolution and clinical applications to liver cancer

Author affiliations

Abstract

Multiphoton microscopy (MPM) is expected to become a powerful clinical tool, with its unique advantages of being label-free, high resolution, deep imaging depth, low light photobleaching and low phototoxicity. Nanomaterials, with excellent physical and chemical properties, are biocompatible and easy to prepare and functionalize. The addition of nanomaterials exactly compensates for some defects of MPM, such as the weak endogenous signal strength, limited imaging materials, insufficient imaging depth and lack of therapeutic effects. Therefore, combining MPM with nanomaterials is a promising biomedical imaging method. Here, we mainly review the principle of MPM and its application in liver cancer, especially in disease evolution and clinical applications, including monitoring tumor progression, diagnosing tumor occurrence, detecting tumor metastasis, and evaluating cancer therapy response. Then, we introduce the latest advances in the combination of MPM with nanomaterials, including the MPM imaging of gold nanoparticles (AuNPs) and carbon dots (CDs). Finally, we also propose the main challenges and future research directions of MPM technology in HCC.

Graphical abstract: Recent advances in multiphoton microscopy combined with nanomaterials in the field of disease evolution and clinical applications to liver cancer

Back to tab navigation

Publication details

The article was received on 10 Jun 2019, accepted on 16 Sep 2019 and first published on 19 Sep 2019


Article type: Review Article
DOI: 10.1039/C9NR04902A
Nanoscale, 2019, Advance Article

  •   Request permissions

    Recent advances in multiphoton microscopy combined with nanomaterials in the field of disease evolution and clinical applications to liver cancer

    H. Lin, T. Fan, J. Sui, G. Wang, J. Chen, S. Zhuo and H. Zhang, Nanoscale, 2019, Advance Article , DOI: 10.1039/C9NR04902A

Search articles by author

Spotlight

Advertisements