Janus Ag/Ag2S Beads as Efficient Photothermal Agents for Eradication of Inflammation and Artery Stenosis
Janus heterostructural materials for photothermal agents with enhanced optical conversion capability are promising for artery inflammation treatment by hyperthermia of macrophages, a primordial part in the artery inflammation response which can deteriorate into atherosclerosis and even break the vessels. Herein, a synthesis route of Janus Ag/Ag2S beads with hydrophilic ligand is designed with the precise control over concentrations, time and surface functionalization. These Ag/Ag2S heterodimers show desirable sizes of around 90 nm in diameter in which Ag nanocrystals have a diameter of around 25 nm, and hold photothermal conversion efficiency up to 50.0% as well as relatively low biotoxicity and good biocompatibility. Importantly, as-prepared Janus Ag/Ag2S beads with a high biological safety can be effectively swallowed by macrophages and have a remarkable benefit of eliminating these cells from the original state of artery inflammation through the high-performed photothermal ability, without causing any further damage to the arteries and major organs in vivo. This study further promotes the development of treatment of vascular inflammation by photothermal melting of macrophage cells in intima environments.