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Fabrication of H2O2-driven nanoreactors for innovative cancer treatments (tbc)

Abstract

The increased production of hydrogen peroxide (H2O2) is a typical feature of cancerous cells. This feature is closely associated with elevated oxidative stress inside solid tumour microenvironments, which thus impairs either the growth of cancer cells or their sensitivity to many cancer therapeutics. To date, numerous innovative strategies that target tumour H2O2 have been designed for effective cancer treatment. More recently, with the rapid advancements of nanomedicine, several nanoreactors, which are highly efficient in converting endogenous H2O2 to more toxic reactive oxygen species, promoting in situ H2O2, or decomposing endogenous H2O2 to molecular oxygen for tumour hypoxia attenuation, have been designed and attempted for effective cancer treatment. This review focuses on the latest progress of such innovative H2O2-driven nanoreactor-mediated cancer treatments. Afterwards, future perspectives on the development of tumour H2O2-driven nanoreactor-mediated cancer treatments and their potential clinical translations will be discussed.

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Publication details

The article was received on 24 May 2019, accepted on 27 Jul 2019 and first published on 29 Jul 2019


Article type: Review Article
DOI: 10.1039/C9NR04418C
Nanoscale, 2019, Accepted Manuscript

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    Fabrication of H2O2-driven nanoreactors for innovative cancer treatments (tbc)

    Z. Dong, Z. Yang, Y. Hao and L. Feng, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR04418C

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