Jump to main content
Jump to site search

Issue 31, 2019
Previous Article Next Article

The pharmaceutical multi-activity of metallofullerenol invigorates cancer therapy

Author affiliations


Currently, cancer continues to afflict humanity. The direct destruction and killing of tumor cells by surgery, radiation and chemotherapy gives rise to many side effects and compromised efficacy. Encouragingly, the rapid development of nanotechnology offers attractive opportunities to revolutionize the current situation of cancer therapy. Metallofullerenol Gd@C82(OH)22, in contrast to chemotherapeutics that directly kill tumor cells, demonstrates anti-tumor behavior with high efficiency and low toxicity by modulating the tumor microenvironment. Furthermore, Gd@C82(OH)22 has been recently reported to specifically target cancer stem cells. In this review, we give a concise introduction to the development of the fullerene family and then report the anti-tumor activity of Gd@C82(OH)22 based on its unique physicochemical characteristics, followed by a comprehensive summary of the anti-tumor biological mechanisms which target different components of the tumor microenvironment as well as the biodistribution and toxicity of Gd@C82(OH)22. Finally, we describe Gd@C82(OH)22 as a “particulate medicine” to highlight its distinctions from conventional “molecular medicine”, with considerable emphasis on the advantages of nanomedicine. The in-depth investigation of Gd@C82(OH)22 undoubtedly provides a constructive reference for the development of other nanomedicines, especially in the fullerene family. The application of nanotechnology in the medical field definitely provides a promising and favorable future for improving the current status of cancer therapy.

Graphical abstract: The pharmaceutical multi-activity of metallofullerenol invigorates cancer therapy

Back to tab navigation

Article information

15 May 2019
19 Jul 2019
First published
20 Jul 2019

Nanoscale, 2019,11, 14528-14539
Article type
Review Article

The pharmaceutical multi-activity of metallofullerenol invigorates cancer therapy

J. Li, L. Chen, H. Su, L. Yan, Z. Gu, Z. Chen, A. Zhang, F. Zhao and Y. Zhao, Nanoscale, 2019, 11, 14528
DOI: 10.1039/C9NR04129J

Social activity

Search articles by author