Issue 27, 2019

CuS–MnS2 nano-flowers for magnetic resonance imaging guided photothermal/photodynamic therapy of ovarian cancer through necroptosis

Abstract

With a high incidence and high mortality rate, ovarian cancer presents a challenge for clinical practice. It is thus extremely urgent to investigate new diagnosis and therapy methods for the treatment of ovarian cancer. Ternary copper-based chalcogenide nanomaterials are attractive owing to their near infrared (NIR) response for cancer theranostic fields. However, improving the theranostic efficiency of these nanomaterials is challenging. Herein, CuS–MnS2 nano-flowers were easily synthesized and under NIR irradiation exhibited a relatively high photothermal conversion efficiency of 67.5% and a simultaneous reactive oxygen species (ROS) generation effect. Owing to these outstanding photothermal/photodynamic effects, excellent tumor ablation results could be achieved by the combined use of CuS–MnS2 nano-flowers and 808 nm NIR laser treatments. The main anticancer mechanism of CuS–MnS2 nano-flowers + NIR was likely necroptosis. In addition, the nano-flowers showed remarkable contrast enhancement according to magnetic resonance imaging (MRI). These CuS–MnS2 nano-flowers could thus serve as a promising multifunctional nanotheranostic agent for MRI and as a photothermal/photodynamic cancer therapy agent through necroptosis.

Graphical abstract: CuS–MnS2 nano-flowers for magnetic resonance imaging guided photothermal/photodynamic therapy of ovarian cancer through necroptosis

Article information

Article type
Paper
Submitted
11 Apr 2019
Accepted
19 Jun 2019
First published
27 Jun 2019

Nanoscale, 2019,11, 12983-12989

CuS–MnS2 nano-flowers for magnetic resonance imaging guided photothermal/photodynamic therapy of ovarian cancer through necroptosis

W. Chen, X. Wang, B. Zhao, R. Zhang, Z. Xie, Y. He, A. Chen, X. Xie, K. Yao, M. Zhong and M. Yuan, Nanoscale, 2019, 11, 12983 DOI: 10.1039/C9NR03114F

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