Biological fate of ingested lipid-based nanoparticles: Current understanding and future directions
In recent decades, LN have received considerable attention as nanoscale delivery systems to improve oral bioavailability of poorly absorbed bioactive compounds for health promotion and disease prevention. However, the scientific studies on the biological fate of orally administered LN are very limited and the molecular mechanisms by which they are absorbed through the intestinal lumen into the circulation remains unclear. This paper aims to provide an overview on the biological fate of orally administered LN by reviewing recent studies on both cell and animal models. In general, the biological fate of ingested LN in gastrointestinal tract is primarily determined by their initial physicochemical characteristics (such as particle size, surface property, composition and structure), and their absorption mainly occurs within the small intestine. In particular, depending upon the composition, LN can be either digestible or indigestible, with two distinct biological fates for each type of LN. The detail absorption mechanisms and uptake pathways at molecular, cellular and whole body levels for each type of LN are discussed in detail. Limitations on current research and our vision for future directions to study the biological fate of ingested LN are also provided in this critical review.
- This article is part of the themed collection: Recent Review Articles