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Issue 23, 2019
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Advancing neodymium single-band nanothermometry

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Abstract

Near-infrared (NIR) emitting contrast agents with integrated optical temperature sensing are highly desirable for a variety of biomedical applications, particularly when subcutaneous target visualization and measurement of its thermodynamic properties are required. To that end, the possibility of using Nd3+ doped LiLuF4 rare-earth nanoparticles (RENPs) as NIR photoluminescent nanothermometers is explored. These RENPs are relatively small, have narrow size distribution, and can easily be core/shell engineered – all combined, these features meet the requirements of biologically relevant and multifunctional nanoprobes. The LiLuF4 host allows to observe the fine Stark structure of the 4F3/24I9/2, 4I11/2, and 4I13/2 optical transitions, each of which can then be used for single-band NIR nanothermometry. The thermometric parameter defined for the most intense Nd3+ emission around 1050 nm, shows high temperature sensitivity (∼0.49% °C−1), and low temperature uncertainty (0.3 °C) as compared to the thermometric parameters defined for the 880 and 1320 nm Nd3+ emissions. Additionally, transient temperature measurements through tissue show that these RENPs can be used to assess fast temperature changes at a tissue depth of 3 mm, while slower temperature changes can be measured at even greater depths. Nd3+ doped LiLuF4 RENPs represent a significant improvement for Nd3+ based single-band photoluminescence nanothermometry, with the possibility of its integration within more sophisticated multifunctional theranostic nanostructures.

Graphical abstract: Advancing neodymium single-band nanothermometry

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Publication details

The article was received on 01 Apr 2019, accepted on 24 May 2019 and first published on 27 May 2019


Article type: Paper
DOI: 10.1039/C9NR02801C
Nanoscale, 2019,11, 11322-11330

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    Advancing neodymium single-band nanothermometry

    A. Skripka, A. Morinvil, M. Matulionyte, T. Cheng and F. Vetrone, Nanoscale, 2019, 11, 11322
    DOI: 10.1039/C9NR02801C

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