Jump to main content
Jump to site search

Issue 34, 2019
Previous Article Next Article

Near-infrared light activatable hydrogels for metformin delivery

Author affiliations


Drug loaded hydrogels have proven to be versatile controlled-release systems. We report here on heat active hydrogel formation by mixing graphene oxide (GO) or carboxyl enriched reduced graphene oxide (rGO-COOH) with metformin hydrochloride, an insulin sensitizer drug currently used as the first line therapy to treat patients with type 2 diabetes. The driving forces of the gelation process between the graphene-based nanomaterial and metformin are hydrogen bonding and electrostatic interactions, weakened at elevated temperature. Using the excellent photothermal properties of the graphene matrixes, we demonstrate that these supramolecular drug reservoirs can be photothermally activated for transdermal metformin delivery. A sustained delivery of metformin was achieved using a laser power of 1 W cm−2. In vitro assessment of the key target Glucose-6 Phosphatase (G6P) gene expression using a human hepatocyte model confirmed that metformin activity was unaffected by photothermal activation. In vivo, metformin was detected in mice plasma at 1 h post-activation of the metformin loaded rGO-COOH gel.

Graphical abstract: Near-infrared light activatable hydrogels for metformin delivery

  • This article is part of the themed collection: Nanocarbons
Back to tab navigation

Publication details

The article was received on 28 Mar 2019, accepted on 25 Jun 2019 and first published on 25 Jun 2019

Article type: Paper
DOI: 10.1039/C9NR02707F
Nanoscale, 2019,11, 15810-15820

  •   Request permissions

    Near-infrared light activatable hydrogels for metformin delivery

    L. Chengnan, Q. Pagneux, A. Voronova, A. Barras, A. Abderrahmani, V. Plaisance, V. Pawlowski, N. Hennuyer, B. Staels, L. Rosselle, N. Skandrani, M. Li, R. Boukherroub and S. Szunerits, Nanoscale, 2019, 11, 15810
    DOI: 10.1039/C9NR02707F

Search articles by author