Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.

Star-Shaped Polypeptides Exhibit Potent Antibacterial Activities


Peptide-based biomaterials are a promising class of antimicrobial agents that work by physically damaging bacterial cell membranes rather than targeting intracellular factors, resulting in less susceptibility to drug resistance. Herein we report the synthesis of cationic, star-shaped polypeptides with 3 to 8 arms and their evaluation as antimicrobial agents against different types of bacteria. The effects of arm number and and side chain group on their antimicrobial activities were systematically investigated. Compared to their linear counterparts, these star-shaped polypeptides exhibited potent antibacterial activity (which may involve adhesion and disruption processes. The increase of arm number can efficiently enhance the antibacterial activities up until 8 arms, which did not exhibit further improvement of antibacterial activities. Poly(L-lysine) (PLL) modified with indole group (PLL-g-Indo) exhibited the best antibacterial activities among all grafted copolypeptides and improved cytotoxic selectivity towards pathogens over mammalian cells without compromising their hemolytic activities. In vivo studies showed that the star-shaped PLL-g-Indo can effectively suppress Enterohaemorrhagic E. coli (EHEC) infection and attenuate the clinical symptoms in mice, suggesting they are promising antimicrobial agents.

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 Mar 2019, accepted on 11 May 2019 and first published on 13 May 2019

Article type: Paper
DOI: 10.1039/C9NR02012H
Nanoscale, 2019, Accepted Manuscript

  •   Request permissions

    Star-Shaped Polypeptides Exhibit Potent Antibacterial Activities

    Y. Chen, Y. Lai, C. Chang, Y. Tsai, C. Tang and J. Jan, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR02012H

Search articles by author