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A single nanowire sensor for intracellular glucose detection

Abstract

Glucose metabolism plays an important role in cell energy supply, and quantitative detection of intracellular glucose level is particularly important for understanding many physiological processes. Glucose electrochemical sensors are widely used for blood and extracellular glucose detection. However, intracellular glucose detection cannot be achieved by these sensors owing to their large size and consequent low spatial resolution. Herein, we developed a single nanowire glucose sensor for electrochemical detection of intracellular glucose by depositing Pt nanoparticles (Pt NPs) on a SiC@C nanowire and further immobilizing glucose oxidase (GOD) there on. Glucose was converted by GOD to an electroactive product H2O2 which was further electro-catalyzed by Pt NPs. The glucose nanowire sensor is endowed with high sensitivity, high spatial-temporal resolution and enzyme specificity due to its nanoscale size and enzymatic reaction. This allows the real-time monitoring of the intracellular glucose level, and the increasement of intracellular glucose level induced by a novel potential hypoglycemic agent, reinforcing its potential application in lowering the blood glucose level. This work provides a versatile method for the construction of enzyme-modified nanosensors to electrochemically detect intracellular non-electroactive molecules, which is of great benefit to the physiological and pathological studies.

  • This article is part of the themed collection: Nanocarbons
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Supplementary files

Publication details

The article was received on 06 Mar 2019, accepted on 30 Apr 2019 and first published on 07 May 2019


Article type: Paper
DOI: 10.1039/C9NR01997A
Nanoscale, 2019, Accepted Manuscript

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    A single nanowire sensor for intracellular glucose detection

    Q. Liao, H. Jiang, X. Zhang, Q. Qiu, Y. Tang, X. Yang, Y. Liu and W. Huang, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR01997A

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