Multifunctional and Flexible ZrO2-Coated EGaIn Nanoparticles for Photothermal Therapy
With the intensive study of liquid metals (LMs), Ga-based LMs attract more attention of biomedical researches for good biocompatibility, ideal fluidity and high thermal conductivity. The concern of liquid metal (LM) applied in cancer treatment is the high surface tension to form unstable nanoparticles. Here, ZrO2 is coated on the LM nanoparticles to form a stable core-shell nanostructure. In particular, the LM nanoparticles coated with ZrO2 and modified by PEG (LM@pZrO2 NPs) still maintain favorable flexibility, which is beneficial for cellular uptake. With the photothermal properties of LM, LM@pZrO2 NPs rapidly warm up and emit amount of heat under NIR laser radiation. It is confirmed that LM@pZrO2 NPs are more effectively internalized by cells and are beneficial to tumor photothermal therapy. This research provides a coating strategy to construct a stable and flexible core-shell LM nanostructure, making it a promising vehicle for nanotheranostics.