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Issue 21, 2019
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Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels – a non-hormonal strategy for the potential treatment of hyperglycemia

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Abstract

We have introduced a non-hormonal hyperglycemia treatment strategy by using an injectable glucose-responsive boronic acid- zwitterionic nanogel. The synthesized system, similar to an artificial liver, is capable of storing/releasing glucose at high/low blood glucose concentrations. In vivo performance revealed that the injection of the nanogels can effectively regulate blood glucose in type 1 diabetic rats for at least 6 hours.

Graphical abstract: Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels – a non-hormonal strategy for the potential treatment of hyperglycemia

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Article information


Submitted
24 Feb 2019
Accepted
14 May 2019
First published
15 May 2019

Nanoscale, 2019,11, 10167-10171
Article type
Communication

Glucose regulation by modified boronic acid-sulfobetaine zwitterionic nanogels – a non-hormonal strategy for the potential treatment of hyperglycemia

A. GhavamiNejad, B. Lu, A. Giacca and X. Y. Wu, Nanoscale, 2019, 11, 10167
DOI: 10.1039/C9NR01687B

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