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Glucose Regulation by Modified Boronic Acid-Sulfobetaine Zwitterionic Nanogels - A Non-Hormonal Strategy for the Potential Treatment of Hyperglycemia

Abstract

We have introduced a non-hormonal hyperglycemia treatment strategy by using an injectable glucose-responsive boronic acid- zwitterionic nanogel. The synthesized system, similar to an artificial liver, is capable of storing/releasing glucose at high/low blood glucose concentrations. In vivo performance revealed that the injection of the nanogels can effectively regulate the blood glucose in type 1 diabetic rats for at least 6 hours.

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Supplementary files

Publication details

The article was received on 24 Feb 2019, accepted on 14 May 2019 and first published on 15 May 2019


Article type: Communication
DOI: 10.1039/C9NR01687B
Nanoscale, 2019, Accepted Manuscript

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    Glucose Regulation by Modified Boronic Acid-Sulfobetaine Zwitterionic Nanogels - A Non-Hormonal Strategy for the Potential Treatment of Hyperglycemia

    A. GhavamiNejad, B. Lu, A. Giacca and X. Y. Wu, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR01687B

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