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Issue 16, 2019
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Assisting anti-PD-1 antibody treatment with a liposomal system capable of recruiting immune cells

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Abstract

Despite the functions of anti-PD-1 antibodies as immune checkpoint regulators, less than 30% of patients exhibit durable therapeutic responses to anti-PD-1 antibodies. Studies have shown that insufficient infiltration of immune cells might limit the outcome of anti-PD-1 therapy. Therefore, we synthesized an immune cell-recruiting liposomal system (FN-nps) to improve this therapeutic strategy. The FN-nps could generate cell debris and expose heat shock protein 70, which could recruit immune cells to tumor sites to assist in anti-PD-1 treatment. In vivo experiments revealed that the FN-nps could assist in anti-PD-1 therapy by increasing the number of lymphocytes in the peripheral blood and tumor site by generating tumor antigens, and this effect was accompanied by an increase in cytokine expression. The number of CTLs increased and mRNA expression levels of cytokines were regulated when the FN-nps were combined with anti-PD-1 therapy. The revealed properties of the liposomal system make it highly promising for assisting in anti-PD-1 antibody immunotherapy in different cancers.

Graphical abstract: Assisting anti-PD-1 antibody treatment with a liposomal system capable of recruiting immune cells

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Publication details

The article was received on 16 Feb 2019, accepted on 28 Mar 2019 and first published on 29 Mar 2019


Article type: Paper
DOI: 10.1039/C9NR01434A
Citation: Nanoscale, 2019,11, 7996-8011

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    Assisting anti-PD-1 antibody treatment with a liposomal system capable of recruiting immune cells

    B. Zhou, Q. Jiang, X. Xiao, X. Xu, Y. Xu, Y. Kong, W. Zhang, Y. Zeng, X. Liu and B. Luo, Nanoscale, 2019, 11, 7996
    DOI: 10.1039/C9NR01434A

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