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Manganese(III)-chelated porphyrin microbubbles for enhanced ultrasound/MR bimodal tumor imaging through ultrasound-mediated micro-to-nano conversion

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Abstract

Manganese(III)-chelated porphyrin microbubbles (MnP-MBs) were fabricated by self-assembly from a Mn-chelated porphyrin lipid followed by encapsulating perfluoropropane—an inert gas. The obtained MnP-MBs exhibited enhanced ultrasound imaging ability after intravenous injection. Under the guidance of ultrasound imaging, MnP-MBs could be converted into nanoparticles in situ with local tumor ultrasound disruption, achieving rapid tumor MRI contrast enhancement within 30 min at a very low Mn injection dose of 0.09 mg (1.65 μmol) per kg.

Graphical abstract: Manganese(iii)-chelated porphyrin microbubbles for enhanced ultrasound/MR bimodal tumor imaging through ultrasound-mediated micro-to-nano conversion

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Publication details

The article was received on 14 Feb 2019, accepted on 03 May 2019 and first published on 07 May 2019


Article type: Communication
DOI: 10.1039/C9NR01373C
Nanoscale, 2019, Advance Article

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    Manganese(III)-chelated porphyrin microbubbles for enhanced ultrasound/MR bimodal tumor imaging through ultrasound-mediated micro-to-nano conversion

    M. Chen, X. Liang and Z. Dai, Nanoscale, 2019, Advance Article , DOI: 10.1039/C9NR01373C

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