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Manganese (III) porphyrin microbubbles for enhanced ultrasound/MR bimodal tumor imaging through ultrasound mediated micro-to-nano conversion

Abstract

Manganese (III) porphyrin microbubbles (MnP-MBs) were fabricated by self-assembly from a Mn chelated porphyrin lipid followed by encapsulating inert gas of perfluoropropane. The obtained MnP-MBs showed ultrasound imaging enhancement after intravenous injection. Under the guidance of ultrasound imaging, MnP-MBs could be in situ converted into nanoparticles with local tumor ultrasound disruption, achieving rapid tumor MRI contrast enhancement within 30 minutes at a very low Mn injection dose of 0.09mg (1.65 μmol ) /kg.

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Supplementary files

Publication details

The article was received on 14 Feb 2019, accepted on 03 May 2019 and first published on 07 May 2019


Article type: Communication
DOI: 10.1039/C9NR01373C
Nanoscale, 2019, Accepted Manuscript

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    Manganese (III) porphyrin microbubbles for enhanced ultrasound/MR bimodal tumor imaging through ultrasound mediated micro-to-nano conversion

    M. Chen, X. Liang and Z. Dai, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR01373C

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