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pH/redox dual-stimuli responsive cross-linked polyphosphazene nanoparticles for multimodal imaging guided chemo-photodynamic therapy

Abstract

Multifunctional nanodrugs with integration of precise diagnostic and effective therapeutic functions have shown great promise in improving the efficacy of cancer therapy. We report herein a simple and effective approach to directly assemble anticancer drug (curcumin), photodynamic agent (Ce6) and tumorenvironment-sensitive molecules into cross-linked polyphosphazene and coat on superparamagnetic Fe3O4 nanoclusters to form discrete nanoparticles (termed as FHCPCe NPs). FHCPCe NPs have high physiological stability and good biocompatibility, and can enhance the accumulation in tumor tissue via enhanced permeability and retention effect. Meanwhile, the FHCPCe NPs exhibits an effective performance of dual-modality magnetic resonance imaging (MRI) due to the Fe3O4 cores and fluorescence imaging (FL) in the xenografted HeLa tumor because of the fluorescence of Ce6. Importantly, under the conditions of supernormal glutathione level and acidic microenvironment in tumor tissue, curcumin and Ce6 can be effectively released by degradation of FHCPCe NPs. Therefore, excellent anti-tumor effects both in vitro and in vivo have been achieved by synergistic chemotherapy/photodynamic therapy (CT/PDT) using the multifunctional NPs. Our study highlights the promise of developing multifunctional nanomaterials for accurate multimodal imaging-guided highly sensitive therapy of cancer.

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Publication details

The article was received on 07 Feb 2019, accepted on 08 Apr 2019 and first published on 10 Apr 2019


Article type: Paper
DOI: 10.1039/C9NR01194C
Citation: Nanoscale, 2019, Accepted Manuscript

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    pH/redox dual-stimuli responsive cross-linked polyphosphazene nanoparticles for multimodal imaging guided chemo-photodynamic therapy

    X. Jing, Z. Zhi, L. Jin, F. wang, Y. Wu, D. Wang, K. Yan, Y. Shao and L. Meng, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR01194C

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