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Boron-Titanate Monolayer Nanosheets for Highly Selective Adsorption of Immunoglobulin G

Abstract

Boron-titanate monolayer nanosheets are prepared through a scalable step by step intercalation approach for anchoring 3-mercaptopropyltriethoxysilane (MPTS) on the surface. MPTS provides clickable sites with 4-vinylphenylboronic acid (VPBA) via a thiol-ene (TE) click reaction to obtain monolayer titanate nanosheets with boronic acid ligands immobilized on the surface. The achieved nanosheets are shortly denoted as VPBA-MPTS-TiNSs, with a lateral dimension of a few dozens of nanometers and with a thickness of ca. 3.5 nm. The nanosheets exhibit a superior adsorption capacity of 1669.7 mg g-1 and favorable selectivity for the adsorption of glycoprotein by employing immunoglobulin G (IgG) as the protein model. The adsorbed IgG is thereafter readily collected by using 0.1% (m/v) cetane trimethyl ammonium bromide (CTAB) as the eluent. The practical applications of VPBA-MPTS-TiNSs are further demonstrated by the selective adsorption/purification of IgG from human serum.

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Publication details

The article was received on 03 Feb 2019, accepted on 12 Apr 2019 and first published on 15 Apr 2019


Article type: Paper
DOI: 10.1039/C9NR01111K
Citation: Nanoscale, 2019, Accepted Manuscript

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    Boron-Titanate Monolayer Nanosheets for Highly Selective Adsorption of Immunoglobulin G

    P. Guo, X. Wang, M. Wang, T. Yang, M. Chen and J. Wang, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR01111K

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