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Issue 16, 2019
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A 1064 nm excitable semiconducting polymer nanoparticle for photoacoustic imaging of gliomas

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Abstract

Photoacoustic (PA) imaging in the second near-infrared (NIR-II) window (especially at 1064 nm) has the benefits of low background signal, high spatial resolution and deep tissue penetration. Here we report a semiconducting polymer nanoparticle (PDPPTBZ NP) and demonstrate its potential as a contrast agent for PA imaging of orthotopic brain tumors, using a 1064 nm pulsed laser as a light source. PDPPTBZ NPs have maximum absorption at 1064 nm with a mass extinction coefficient of 43 mL mg−1 cm−1, which is the highest value reported so far in this region. The high photothermal conversion efficiency (67%) and near non-fluorescence impart PDPPTBZ NPs with excellent PA properties. We used PDPPTBZ NP-containing agar gel phantoms even at a low concentration (50 μg mL−1) to successfully image to a depth of 4 cm (of chicken-breast tissue), with an ultralow power fluence (4 mJ cm−2). Furthermore, we could clearly visualize a glioma tumor in a mouse at a depth of 3.8 mm below the skull. This study demonstrates that PDPPTBZ NPs display great potential as a NIR-II PA contrast agent for high quality deep tissue imaging.

Graphical abstract: A 1064 nm excitable semiconducting polymer nanoparticle for photoacoustic imaging of gliomas

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Publication details

The article was received on 18 Jan 2019, accepted on 14 Mar 2019 and first published on 21 Mar 2019


Article type: Paper
DOI: 10.1039/C9NR00552H
Citation: Nanoscale, 2019,11, 7754-7760

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    A 1064 nm excitable semiconducting polymer nanoparticle for photoacoustic imaging of gliomas

    Y. Yang, J. Chen, Y. Yang, Z. Xie, L. Song, P. Zhang, C. Liu and J. Liu, Nanoscale, 2019, 11, 7754
    DOI: 10.1039/C9NR00552H

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