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A ratiometric theranostic nanoprobe for pH imaging-guided photodynamic therapy

Abstract

Abnormal pH microenvironment goes along with the development of tumor, which also affects the therapeutic efficiency of anti-tumor drugs. In this work, a Fӧrster resonance energy transfer (FRET)-based theranostic fluorescent nanoprobe was constructed for simultaneous ratiometric pH sensing and tumor targeted photodynamic therapy. Based on the FRET process between Rhodamine B and protoporphyrin IX (PpIX), the fabricated nanoprobe exhibited an excellent pH responsiveness in both solutions and live cells with the ratiometric fluorescence changes. Moreover, this ratiometric pH fluorescent nanoprobe also possessed the capability of pH-responsive singlet oxygen (1O2) generation under light irradiation, guiding a robust photodynamic therapy in a pH-dependent manner. Benefiting from the enhanced permeability and retention (EPR) effect, the nanoprobe could significantly inhibit the tumor growth and metastasis via the targeted photodynamic therapy in vivo. This work presented a novel paradigm for precise tumor theranostics by ratiometric pH fluorescence imaging-guided photodynamic therapy.

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Publication details

The article was received on 04 Jan 2019, accepted on 11 Apr 2019 and first published on 12 Apr 2019


Article type: Paper
DOI: 10.1039/C9NR00093C
Citation: Nanoscale, 2019, Accepted Manuscript

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    A ratiometric theranostic nanoprobe for pH imaging-guided photodynamic therapy

    H. Cheng, G. Fan, J. Fan, L. Zhao, R. Zheng, X. Xu and S. Li, Nanoscale, 2019, Accepted Manuscript , DOI: 10.1039/C9NR00093C

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