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Issue 4, 2019
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Zapped assembly of polymeric (ZAP) nanoparticles for anti-cancer drug delivery

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Abstract

The starting hypothesis for this work was that microwave synthesis could enable the rapid assembly of polymers into size-specific nanoparticles (NPs). The Zapped Assembly of Polymeric (ZAP) NPs was initially realized using poly(lactic-co-glycolic acid)-poly(ethylene glycol) (PLGA-PEG) block copolymers and distinct microwave reaction parameters. A library of polymeric NPs was generated with sizes ranging from sub-20 nm to 350 nm and low polydispersity. Select ZAP NPs were synthesized in 30 seconds at different scales and concentrations, up to 200 mg and 100 mg mL−1, without substantial size variation. ZAP NPs with diameters of 25 nm, 50 nm, and 100 nm were loaded with the chemotherapeutic paclitaxel (PXL), demonstrated unique release profiles, and exhibited dose-dependent cytotoxicity similar to Taxol. Incorporation of d-alpha tocopheryl polyethylene glycol succinate (TPGS) and PLGA33k allowed for the production of a sub-40 nm NP with an exceptionally high loading of PXL (12.6 wt%, ca. 7 times the original NP) and a slower release profile. This ZAP NP platform demonstrated scalable, flexible, and tunable synthesis with potential toward clinical scale production of size-specific drug carriers.

Graphical abstract: Zapped assembly of polymeric (ZAP) nanoparticles for anti-cancer drug delivery

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Supplementary files

Article information


Submitted
08 Dec 2018
Accepted
29 Dec 2018
First published
14 Jan 2019

Nanoscale, 2019,11, 1847-1855
Article type
Paper

Zapped assembly of polymeric (ZAP) nanoparticles for anti-cancer drug delivery

S. S. Dunn, J. C. Luft and M. C. Parrott, Nanoscale, 2019, 11, 1847
DOI: 10.1039/C8NR09944H

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