Jump to main content
Jump to site search


Minor components of aminoglycosides: recent advances in their biosynthesis and therapeutic potential

Author affiliations

Abstract

Covering: up to 2019

There is significant demand for new aminoglycoside antibiotics due to the widespread emergence of multidrug-resistant Gram-negative bacteria and their high toxicity, but these are not easily accessible in nature because their biosynthetic gene clusters are less commonly found in actinomycetes than are other natural products. Mining minor aminoglycoside components whose pharmacological activity has not yet been assessed could be an alternative approach for the development of next-generation antibiotics for use in the post-antibiotic era. Here, we review the biosynthetic steps responsible for the structural diversity of aminoglycosides and highlight current developments regarding the use of natural minor and semi-synthetic aminoglycosides as promising therapeutic leads or candidates.

Graphical abstract: Minor components of aminoglycosides: recent advances in their biosynthesis and therapeutic potential

Back to tab navigation

Publication details

The article was received on 05 Jul 2019 and first published on 10 Sep 2019


Article type: Highlight
DOI: 10.1039/C9NP00041K
Nat. Prod. Rep., 2019, Advance Article

  •   Request permissions

    Minor components of aminoglycosides: recent advances in their biosynthesis and therapeutic potential

    Y. H. Ban, M. C. Song, J. W. Park and Y. J. Yoon, Nat. Prod. Rep., 2019, Advance Article , DOI: 10.1039/C9NP00041K

Search articles by author

Spotlight

Advertisements