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Recent advances in HemN-like radical S-adenosyl-l-methionine enzyme-catalyzed reactions

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Abstract

Covering: 2012 to 2019

HemN-like radical S-adenosyl-L-methionine (SAM) enzymes have been recently disclosed to catalyze diverse chemically challenging reactions from primary to secondary metabolic pathways. In this highlight, we summarize the reaction examples catalyzed by HemN-like enzymes to date and the enzymatic mechanisms reported. From the recent mechanistic investigations, we reason that there is a shared initiating mechanism wherein a characteristic SAM methylene radical is proposed to abstract a hydrogen atom from an sp3 carbon or add onto an sp2 carbon center although variations occur thereafter from reaction to reaction, as well as providing a brief insight into some future prospects.

Graphical abstract: Recent advances in HemN-like radical S-adenosyl-l-methionine enzyme-catalyzed reactions

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Publication details

The article was received on 23 May 2019 and first published on 10 Jul 2019


Article type: Highlight
DOI: 10.1039/C9NP00032A
Nat. Prod. Rep., 2019, Advance Article

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    Recent advances in HemN-like radical S-adenosyl-L-methionine enzyme-catalyzed reactions

    W. Jin, S. Wu, Y. Xu, H. Yuan and G. Tang, Nat. Prod. Rep., 2019, Advance Article , DOI: 10.1039/C9NP00032A

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