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Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products

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Abstract

Covering: up to 2019

The discovery of new bioactive natural products gained momentum during the last few decades, resulting from instrumentation advances, from the expansion of genome mining and regulation, as well as by exploration of untapped biological sources. However, water-soluble, volatile, minor and photosensitive natural products are yet poorly known. This review discusses the literature reporting the isolation strategies for some of these metabolites. Analysis of minor metabolites at sub-milligram level are also presented, since analytical instrumentation enabling structure assignment in minute quantities is now routine. Major trends related to natural products discovery are discussed, under the light of further developments in biodiscovery.

Graphical abstract: Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products

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Publication details

The article was received on 01 Feb 2019 and first published on 03 May 2019


Article type: Review Article
DOI: 10.1039/C9NP00009G
Nat. Prod. Rep., 2019, Advance Article

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    Approaches for the isolation and identification of hydrophilic, light-sensitive, volatile and minor natural products

    R. G. S. Berlinck, A. F. Monteiro, A. F. Bertonha, D. I. Bernardi, J. R. Gubiani, J. Slivinski, L. F. Michaliski, L. A. C. Tonon, V. A. Venancio and V. F. Freire, Nat. Prod. Rep., 2019, Advance Article , DOI: 10.1039/C9NP00009G

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