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Catalytic asymmetric dearomatization (CADA) reaction-enabled total synthesis of indole-based natural products

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Abstract

Covering: 2000 up to 2019.

Catalytic asymmetric dearomatization (CADA) reactions have witnessed considerable development in recent years. As the most extensively studied sub-branch, asymmetric dearomatization reactions of indole derivatives have attracted particular interest from the synthetic organic community since the molecular complexity can be rapidly enhanced with this method and the asymmetric total synthesis of a series of alkaloid natural products may be achieved with this strategy. In this review, we present the recent contributions in this dynamic area. The synthetic details are documented according to their different dearomative cyclization strategies.

Graphical abstract: Catalytic asymmetric dearomatization (CADA) reaction-enabled total synthesis of indole-based natural products

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Publication details

The article was received on 22 Dec 2018 and first published on 06 Mar 2019


Article type: Review Article
DOI: 10.1039/C8NP00098K
Citation: Nat. Prod. Rep., 2019, Advance Article

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    Catalytic asymmetric dearomatization (CADA) reaction-enabled total synthesis of indole-based natural products

    C. Zheng and S. You, Nat. Prod. Rep., 2019, Advance Article , DOI: 10.1039/C8NP00098K

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