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Issue 2, 2019
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2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis

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Abstract

Covering: up to April 2018

2-Formylpyrroles are ubiquitous in nature, arising from the non-enzymatic Maillard reactions of amines and sugars. Often confused for secondary metabolites, these Maillard products display interesting biological activities including hepatoprotective, immunostimulatory, antiproliferative and antioxidant effects. This review presents all 2-formylpyrrole natural products reported to date and identifies structural sub-classes for their categorisation. The origin, biological activity and chemical syntheses of these natural products are discussed herein.

Graphical abstract: 2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis

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Publication details

The article was received on 13 Jun 2018 and first published on 24 Jul 2018


Article type: Review Article
DOI: 10.1039/C8NP00051D
Citation: Nat. Prod. Rep., 2019,36, 289-306
  • Open access: Creative Commons BY license
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    2-Formylpyrrole natural products: origin, structural diversity, bioactivity and synthesis

    James M. Wood, D. P. Furkert and M. A. Brimble, Nat. Prod. Rep., 2019, 36, 289
    DOI: 10.1039/C8NP00051D

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