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Issue 1, 2019
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Natural product syntheses via carbonylative cyclizations

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Covering: 2000–2018

In this review, we highlight recent examples of natural product total syntheses employing transition metal-mediated/catalyzed carbonylative cyclization strategies to build key ring systems. It mainly covers carbonylative cyclizations for the construction of O-heterocycles, N-heterocycles and carbocycles including cyclic ketones and phenols. The reaction types include carbonylation of epoxide to β-lactones, carbonylative (macro)lactonization/lactamization, the Semmelhack reaction, tandem hydroformylation–cyclization, the Pauson–Khand reaction, carbonylative C–H activation cyclization, the Stille/Suzuki carbonylation, [n + m + 1] carbonylative cycloaddition, the Dötz annulation, and others.

Graphical abstract: Natural product syntheses via carbonylative cyclizations

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Article information

09 Apr 2018
First published
20 Jun 2018

Nat. Prod. Rep., 2019,36, 174-219
Article type
Review Article
Author version available

Natural product syntheses via carbonylative cyclizations

K. Ma, B. S. Martin, X. Yin and M. Dai, Nat. Prod. Rep., 2019, 36, 174
DOI: 10.1039/C8NP00033F

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