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Harnessing diverse transcriptional regulators for natural product discovery in fungi

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Abstract

Covering: Up to March 2019

Secondary metabolites (SMs) are chemical entities produced by organisms in response to environmental stimuli and as a defense against biological warfare. The production of SMs is controlled by a hierarchical regulatory network involving core factors that orchestrate transcriptional activation of SM gene clusters. In the past few years, significant achievements have been made in the discovery of novel fungal natural products by genetic manipulations of various types of transcriptional regulators. In this review, we summarized the representative regulators for the activation of fungal secondary metabolism and focused on the strategies for the exploitation of these regulators and their application in finding novel structures.

Graphical abstract: Harnessing diverse transcriptional regulators for natural product discovery in fungi

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Publication details

The article was received on 27 Mar 2018 and first published on 29 Apr 2019


Article type: Highlight
DOI: 10.1039/C8NP00027A
Nat. Prod. Rep., 2019, Advance Article

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    Harnessing diverse transcriptional regulators for natural product discovery in fungi

    H. Lyu, H. Liu, N. P. Keller and W. Yin, Nat. Prod. Rep., 2019, Advance Article , DOI: 10.1039/C8NP00027A

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