Issue 2, 2020

Sensing of zinc ions and sulfide using a highly practical and water-soluble fluorescent sensor: applications in test kits and zebrafish

Abstract

A novel practical fluorescent sensor AMPQ (2-((3-morpholinopropyl)amino)-N-((quinolin-8-yl)acetamide)) was designed and synthesized. In bis-tris buffer, AMPQ displayed highly practical and selective fluorescence recognition of Zn2+, clearly discriminating it from Cd2+ and other cations. Moreover, the AMPQ–Zn2+ complex exhibited a fluorescence “turn-off” response to S2− with exceptional selectivity via a S2−-induced Zn2+ displacement approach. The detection limits (0.29 and 2.39 μM) of AMPQ for Zn2+ and S2− were much lower than the WHO guidelines (76.0 and 14.7 μM), respectively. Importantly, sensor AMPQ could be applied in various practical applications such as in real water samples and test kits. In particular, AMPQ could monitor both Zn2+ and S2− in live zebrafish, with a detection limit of 0.74 μM for Zn2+, which is the lowest among sensors previously reported for the relay detection of Zn2+ and S2−. The sensing process of AMPQ toward Zn2+ and S2− was evaluated by UV-vis and fluorescence spectroscopy, Job plots, ESI-MS, 1H NMR titrations, and calculations.

Graphical abstract: Sensing of zinc ions and sulfide using a highly practical and water-soluble fluorescent sensor: applications in test kits and zebrafish

Supplementary files

Article information

Article type
Paper
Submitted
10 Oct 2019
Accepted
19 Nov 2019
First published
29 Nov 2019

New J. Chem., 2020,44, 442-449

Sensing of zinc ions and sulfide using a highly practical and water-soluble fluorescent sensor: applications in test kits and zebrafish

D. Yun, J. B. Chae, H. So, H. Lee, K. Kim and C. Kim, New J. Chem., 2020, 44, 442 DOI: 10.1039/C9NJ05057D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements