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PIDA-mediated α-C–H functionalization of enaminones: the synthesis of thiocyano enaminones and chromones in water

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Abstract

Herein, an efficient, metal-free process for the α-C–H thiocyanation of enaminones was developed using PhI(OAc)2 as an oxidant at room temperature in an aqueous medium. Various SCN-containing enaminones and chromones with broad functional groups were synthesized in moderate to good yields in the presence of KSCN. In addition, 3-selenocyanochromone was synthesized using this fast, green, metal-free approach.

Graphical abstract: PIDA-mediated α-C–H functionalization of enaminones: the synthesis of thiocyano enaminones and chromones in water

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Publication details

The article was received on 05 Sep 2019, accepted on 01 Oct 2019 and first published on 01 Oct 2019


Article type: Letter
DOI: 10.1039/C9NJ04580E
New J. Chem., 2019, Advance Article

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    PIDA-mediated α-C–H functionalization of enaminones: the synthesis of thiocyano enaminones and chromones in water

    Z. Yang, L. Hu, T. Cao, L. An, L. Li, T. Yang and C. Zhou, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ04580E

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