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Transition-Metal-Free Synthesis of Fluoroalkyltated Oxindoles via Base-Mediated Fluoroalkylation of N-arylacrylamides with RFI

Abstract

A base-mediated tandem radical procure for the synthesis of fluoroalkylated oxindoles via cyclization reaction of N-arylacrylamides with RFI is developed. With this facile and practical synthetic method, a wide range of 3-(2-perfluoroalkyl)indolin-2-ones is obtained in good yields with highly stereoselectivity.

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Publication details

The article was received on 29 Aug 2019, accepted on 26 Oct 2019 and first published on 30 Oct 2019


Article type: Paper
DOI: 10.1039/C9NJ04458B
New J. Chem., 2019, Accepted Manuscript

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    Transition-Metal-Free Synthesis of Fluoroalkyltated Oxindoles via Base-Mediated Fluoroalkylation of N-arylacrylamides with RFI

    Z. Yang, Y. Cheng, J. Long, X. Feng, R. Tang and J. Wei, New J. Chem., 2019, Accepted Manuscript , DOI: 10.1039/C9NJ04458B

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