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A new enantioselective synthesis of antiobesity drug lorcaserin

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Abstract

A simple and efficient enantioselective synthesis of anti-obesity drug lorcaerin starting from easily accessible 3-chlorostyrene oxide has been described for the first time employing hydrolytic kinetic resolution as a source of chirality. The protocol might also be useful in the synthesis of structural variants of lorcaserin.

Graphical abstract: A new enantioselective synthesis of antiobesity drug lorcaserin

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Publication details

The article was received on 15 Aug 2019, accepted on 04 Oct 2019 and first published on 07 Oct 2019


Article type: Paper
DOI: 10.1039/C9NJ04234B
New J. Chem., 2019, Advance Article

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    A new enantioselective synthesis of antiobesity drug lorcaserin

    G. S. Ghotekar, D. A. More, V. Nalla and M. Muthukrishnan, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ04234B

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