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Issue 41, 2019
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A ureido-pyrimidone based aspartic acid derivative: synthesis and pH-responsive self-assembly in water

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Abstract

Due to its high association constants, 2-ureido-4[1H]-6-methyl-pyrimidinone (UPy) has been widely used in the fabrication of functional supramolecular assemblies and materials. In this work, a UPy-based aspartic acid derivative, 2-(3-(6-(3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido)hexyl)ureido)succinic acid (UPy-Asp), was synthesized using UPy-based isocyanates and aspartic acid. UPy-Asp exhibited a pH-responsive self-assembling behavior in an aqueous solution due to the aspartic acid moieties. The UPy-Asp aggregates can be repeatedly transformed between nanowires and nanosheets by changing the pH, and can be used as templates for silver nanofibers or silver nanosheets.

Graphical abstract: A ureido-pyrimidone based aspartic acid derivative: synthesis and pH-responsive self-assembly in water

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Publication details

The article was received on 24 Jul 2019, accepted on 20 Sep 2019 and first published on 23 Sep 2019


Article type: Paper
DOI: 10.1039/C9NJ03830B
New J. Chem., 2019,43, 16226-16231

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    A ureido-pyrimidone based aspartic acid derivative: synthesis and pH-responsive self-assembly in water

    H. Jiang, L. Kan, Z. Wang, X. Zhang, G. Wang, S. Gao, N. Ma and H. Wei, New J. Chem., 2019, 43, 16226
    DOI: 10.1039/C9NJ03830B

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