Issue 48, 2019

Hyaluronic acid decorated pH- and temperature-induced injectable bioconjugates for sustained delivery of bioactive factors and highly efficient wound regeneration

Abstract

Microporous injectable bioconjugates, composed of hyaluronic acid–poly(β-aminoester urethane), were prepared by the amination of synthetic copolymers and successive post modification using natural polymers. Strinkingly, the free flowing bioconjugates can seal cutaneous wounds due to their sharp sol-to-gel phase transition. The sustained delivery of bioactive factors and wound regeneration performance of the bioconjugates were examined in vivo.

Graphical abstract: Hyaluronic acid decorated pH- and temperature-induced injectable bioconjugates for sustained delivery of bioactive factors and highly efficient wound regeneration

Supplementary files

Article information

Article type
Letter
Submitted
16 Jul 2019
Accepted
18 Nov 2019
First published
22 Nov 2019

New J. Chem., 2019,43, 18979-18982

Hyaluronic acid decorated pH- and temperature-induced injectable bioconjugates for sustained delivery of bioactive factors and highly efficient wound regeneration

T. Thambi, V. H. Giang Phan, S. H. Kim, T. M. Duy Le and D. S. Lee, New J. Chem., 2019, 43, 18979 DOI: 10.1039/C9NJ03687C

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