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Hyaluronic acid decorated pH- and temperature-induced injectable bioconjugates for sustained delivery of bioactive factors and highly efficient wound regeneration

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Abstract

Microporous injectable bioconjugates, composed of hyaluronic acid–poly(β-aminoester urethane), were prepared by the amination of synthetic copolymers and successive post modification using natural polymers. Strinkingly, the free flowing bioconjugates can seal cutaneous wounds due to their sharp sol-to-gel phase transition. The sustained delivery of bioactive factors and wound regeneration performance of the bioconjugates were examined in vivo.

Graphical abstract: Hyaluronic acid decorated pH- and temperature-induced injectable bioconjugates for sustained delivery of bioactive factors and highly efficient wound regeneration

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Publication details

The article was received on 16 Jul 2019, accepted on 18 Nov 2019 and first published on 22 Nov 2019


Article type: Letter
DOI: 10.1039/C9NJ03687C
New J. Chem., 2019, Advance Article

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    Hyaluronic acid decorated pH- and temperature-induced injectable bioconjugates for sustained delivery of bioactive factors and highly efficient wound regeneration

    T. Thambi, V. H. Giang Phan, S. H. Kim, T. M. Duy Le and D. S. Lee, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ03687C

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