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Polymeric template assisted synthesis of monodisperse-porous manganese oxide microspheres: a new nanozyme with oxidase-like activity allowing biomolecule determination via bimodal sensing

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Abstract

“Monodisperse-porous manganese oxide (MnOx) microspheres” that could not be obtained by current protocols were synthesized by a new template assisted method, using porous poly(methacrylic acid-co-ethylene dimethacrylate) microspheres as a template. Through the developed method, monodisperse MnOx microspheres 3.7 μm in size, with a specific surface area of 71 m2 g−1, a mean pore size of 15 nm and a porous structure covering mesopores and macropores, were obtained by the calcination of polymer/manganese oxide composite microspheres at 380 °C. A transition in the porous structure from mesoporous to macroporous form and a transition in the crystal structure from monoclinic Mn5O8 to α-MnO2 were observed with increasing calcination temperature. MnOx microspheres with appropriate size and porous properties for using them as a permeable stationary phase in a continuous microcolumn were also synthesized for the first time. The monodisperse-porous MnOx microspheres exhibited oxidase mimetic activity at neutral pH, using o-phenylenediamine (OPDA) as the substrate. The enzyme mimetic characteristics of the microspheres were also adjusted by controlling their porous properties. The decomposition of MnOx microspheres to Mn2+ ions in the presence of ascorbic acid (AA) was evaluated for bimodal sensing of this agent for the first time, which could not be achieved with MnO2 nanosheets as a frequently tried nanomaterial for biosensing applications. The particle size of the synthesized nanozyme in the micron-size range and selected substrate providing a fluorescent product allowed determination of the AA concentration via both colorimetric and fluorometric methods. The MnOx microspheres are new materials with superiorities in biosensing, column chromatography, nanocatalysis and supercapacitor applications.

Graphical abstract: Polymeric template assisted synthesis of monodisperse-porous manganese oxide microspheres: a new nanozyme with oxidase-like activity allowing biomolecule determination via bimodal sensing

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Publication details

The article was received on 09 Jul 2019, accepted on 02 Nov 2019 and first published on 04 Nov 2019


Article type: Paper
DOI: 10.1039/C9NJ03527C
New J. Chem., 2019, Advance Article

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    Polymeric template assisted synthesis of monodisperse-porous manganese oxide microspheres: a new nanozyme with oxidase-like activity allowing biomolecule determination via bimodal sensing

    R. Babacan Tosun, Ç. Kip and A. Tuncel, New J. Chem., 2019, Advance Article , DOI: 10.1039/C9NJ03527C

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