Synthesis, characterization and photodynamic activity of Sn(IV) triarylcorroles with red-shifted Q bands
Two Sn(IV) triarylcorroles were synthesised and characterized. The absorption spectra of thien-2-yl containing tin(IV)corrole (1-Sn) is red shifted compared to its phenyl analogue (2-Sn) and shows no sign of aggregation in solution. 1-Sn exhibited singlet oxygen quantum yields of 0.78 and 0.54 in DMF, and have triplet lifetime of 31 and 50 µs, respectively. Time dependent cellular uptake in MCF-7 cells for 1-Sn reached a peak at 24h, and 1-Sn found to be more liphophilic than 2-Sn. 1-Sn showed good photo-cytotoxicity on exposure to a Thorlabs 625 nm LED with an IC50 value of 3.2 μM and remained inactive in the dark.